I occasionally encounter cases where the keyless entry does not unlock the car when I grab the handle (I'm almost always using the driver's side). Sometimes there will be a soft click from all the doors, but they do not unlock. Sometimes there is no reaction from the car at all.
I usually just let go of the handle, wait a second and then grab it again more "deliberately". It usually works the second time. I'm not sure what the "magic" is. It might have something to do with having your hand closer to, or in contact with, that black "pad" on the handle.